Description:
Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was discovered and developed by the European pharmaceutical company Servier Laboratories Ltd. Servier continue to develop the drug and conduct phase III trials in the European Union. In 2005 Servier submitted Agomelatine to the European Medicines Agency (EMEA). On 27 July 2006 the Committee for Medical Products for Human Use (CHMP) of the EMEA recommended a refusal of the marketing authorisation of Valdoxan/Thymanax. The major concern was that efficacy had not been sufficiently shown. In 2006 Servier sold the rights to develop Agomelatine in the US to Novartis.
Basic Details:
Chemical name: AGOMELATINE
MF: C15H17NO2
MW: 243.30098
CAS: 138112-76-2
Appearance: white powder
Package: 25kg/Drum
Usage: Antidepressant Drug
COA:
Â
Product name
Agomelatine
CAS No.
138112-76-2
Outer Packing
25kg/Drum
Â
Production date
2017.3.23
Shelf life
1 year
Standard adopted
enterprise standard
Items of analysis
Specification
Results
Appearance
Â
White or white crystalline powder.
Qualified
Â
MP
Â
107ºC~110ºC
Â
107.6~108.8ºC
Â
ignition residue
Â
≤0.1%
Â
0.07%
Â
Loss on dry
Â
≤0.5%
Â
0.22%
Â
Heavy Metal
Â
NMT20ppm
Â
conforms
Â
Related substance
Â
NMT0.1%
Â
Qualified
Â
Total Impurity
Â
NMT0.3%
Â
Qualified
Â
Assay
Â
≥99%
Â
99.9%
Â
Conclusion
Qualified
Medical uses:
Major depressive disorder:
Agomelatine is indicated for the treatment of major depressive episodes in adults.Ten placebo controlled trials have been performed to investigate the short term efficacy of agomelatine in major depressive disorder. At the end of treatment, significant efficacy was demonstrated in six of the ten short-term double-blind placebo-controlled studies.Two were considered "failed" trials, as comparators of established efficacy failed to differentiate from placebo. Efficacy was also observed in more severely depressed patients in all positive placebo-controlled studies.The maintenance of antidepressant efficacy was demonstrated in a relapse prevention study.A large meta-analysis of 20 trials with 7460 participants found agomelatine to be as effective as standard antidepressants.
Results of the meta-analysis of three positive, randomized, double-blind, placebo controlled studies in 357 patients treated with agomelatine and 360 patients treated with placebo show that agomelatine is effective in treating severe depression. Its antidepressant effect is greater for more severe depression. In patients with a greater baseline score (>30 on HAMD17 scale), the agomelatine-placebo difference was of 4.53 points.Controlled studies in humans have shown that agomelatine is at least as effective as the SSRI antidepressants paroxetine, sertraline, escitalopram, and fluoxetine in the treatment of major depression.
Packaging:
We have professional team for package and shipment.Special way to ship 100 ml to 100L liquids at one time to your country.Fast and discreet shipment could be arranged for customs pass Guaranteed.
Competitive Advantage:
Â
1.We have engaged in this line has many years of experience, our reputation is our guarantee of quality.High quality, competitive price, fast delivery, safe shipping and considerate after-sale service gain the trust and praise from the customers all over the world. 2.Saichuang Technology Co., ltd is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. 3.Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month. 4.Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed.100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil;98% pass to Germany, Russia, Australia, New Zealand. 5.Our products and services will focus on the largest customer demand,We hold the greatest enthusiasm and sincere cooperation with each customer.
We supply a variety of chemicals with competitive price and high quality including:
Food additive
Feed additive
Pharmaceutical raw materials
Steroid hormone
Cinnamate series
Pesticides
Veterinary medicine
Flavoring and essence
Plant extract
Paint and coating
Inorganic chemicals
Organic chemicals
Amino acid,
Vitamins.
Other products you may like.
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How to proceed order:
1.Please let me know the items you are looking for, quantity, and the destination country.
2.We send the detailed price of our product and offer the suitable shipping method for your reference.
3.You confirm the order and pay money 100% in advance and send us the detailed address.
4.We will pack your parcel and arrange to shipment according to your requirements
5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
6.After you receiving parcel,we will offer you best after-sale.
If you have any questions, please feel free to contact me:
Miss Debbie:Â +8618872220738
Antidepressant Raw Material Drug Agomelatine White Powder CAS: 138112-76-2
Description:
Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was discovered and developed by the European pharmaceutical company Servier Laboratories Ltd. Servier continue to develop the drug and conduct phase III trials in the European Union. In 2005 Servier submitted Agomelatine to the European Medicines Agency (EMEA). On 27 July 2006 the Committee for Medical Products for Human Use (CHMP) of the EMEA recommended a refusal of the marketing authorisation of Valdoxan/Thymanax. The major concern was that efficacy had not been sufficiently shown. In 2006 Servier sold the rights to develop Agomelatine in the US to Novartis.
Basic Details:
Chemical name: AGOMELATINE
MF: C15H17NO2
MW: 243.30098
CAS: 138112-76-2
Appearance: white powder
Package: 25kg/Drum
Usage: Antidepressant Drug
COA:
Â
Product name
Agomelatine
CAS No.
138112-76-2
Outer Packing
25kg/Drum
Â
Production date
2017.3.23
Shelf life
1 year
Standard adopted
enterprise standard
Items of analysis
Specification
Results
Appearance
Â
White or white crystalline powder.
Qualified
Â
MP
Â
107ºC~110ºC
Â
107.6~108.8ºC
Â
ignition residue
Â
≤0.1%
Â
0.07%
Â
Loss on dry
Â
≤0.5%
Â
0.22%
Â
Heavy Metal
Â
NMT20ppm
Â
conforms
Â
Related substance
Â
NMT0.1%
Â
Qualified
Â
Total Impurity
Â
NMT0.3%
Â
Qualified
Â
Assay
Â
≥99%
Â
99.9%
Â
Conclusion
Qualified
Medical uses:
Major depressive disorder:
Agomelatine is indicated for the treatment of major depressive episodes in adults.Ten placebo controlled trials have been performed to investigate the short term efficacy of agomelatine in major depressive disorder. At the end of treatment, significant efficacy was demonstrated in six of the ten short-term double-blind placebo-controlled studies.Two were considered "failed" trials, as comparators of established efficacy failed to differentiate from placebo. Efficacy was also observed in more severely depressed patients in all positive placebo-controlled studies.The maintenance of antidepressant efficacy was demonstrated in a relapse prevention study.A large meta-analysis of 20 trials with 7460 participants found agomelatine to be as effective as standard antidepressants.
Results of the meta-analysis of three positive, randomized, double-blind, placebo controlled studies in 357 patients treated with agomelatine and 360 patients treated with placebo show that agomelatine is effective in treating severe depression. Its antidepressant effect is greater for more severe depression. In patients with a greater baseline score (>30 on HAMD17 scale), the agomelatine-placebo difference was of 4.53 points.Controlled studies in humans have shown that agomelatine is at least as effective as the SSRI antidepressants paroxetine, sertraline, escitalopram, and fluoxetine in the treatment of major depression.
Packaging:
We have professional team for package and shipment.Special way to ship 100 ml to 100L liquids at one time to your country.Fast and discreet shipment could be arranged for customs pass Guaranteed.
Competitive Advantage:
Â
1.We have engaged in this line has many years of experience, our reputation is our guarantee of quality.High quality, competitive price, fast delivery, safe shipping and considerate after-sale service gain the trust and praise from the customers all over the world. 2.Saichuang Technology Co., ltd is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. 3.Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month. 4.Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed.100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil;98% pass to Germany, Russia, Australia, New Zealand. 5.Our products and services will focus on the largest customer demand,We hold the greatest enthusiasm and sincere cooperation with each customer.
We supply a variety of chemicals with competitive price and high quality including:
Food additive
Feed additive
Pharmaceutical raw materials
Steroid hormone
Cinnamate series
Pesticides
Veterinary medicine
Flavoring and essence
Plant extract
Paint and coating
Inorganic chemicals
Organic chemicals
Amino acid,
Vitamins.
Other products you may like.
Antineoplastic Crude Drug
L-Triiodothyronine(T3)(CAS No:55-06-1)
Anastrozol(Arimidex)(CAS:120511-73-1)
Trilostane(CAS:13647-35-3)
Formestan(CAS:566-48-3)
(Aromasin)(CAS:107868-30-4)
Weight Loss Drug
Â
L(-)-Carnitine(CAS:541-15-1)
Rimonaban* (CAS:158681-13-1)
Local Anaesthetic Drug
Benzocaine(CAS No:94-09-7)
Tetracaine hydrochloride (CAS:136-47-0)
Procaine hydrochloride (CAS No:51-05-8)
Lidocaine Hydrochloride (CAS No:6108-05-0)
Estrogen Hormone
Progesterone (CAS:57-83-0)
Estradiol (CAS:50-28-2)
Estriol (CAS:50-27-1)
Estradiol valerate (CAS:979-32-8)
Diethylstilbestrol (CAS:56-53-1)
Hexestrol (CAS:84-16-2)
How to proceed order:
1.Please let me know the items you are looking for, quantity, and the destination country.
2.We send the detailed price of our product and offer the suitable shipping method for your reference.
3.You confirm the order and pay money 100% in advance and send us the detailed address.
4.We will pack your parcel and arrange to shipment according to your requirements
5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
6.After you receiving parcel,we will offer you best after-sale.
If you have any questions, please feel free to contact me:
Miss Debbie:Â +8618872220738
Antidepressant Raw Material Drug Agomelatine White Powder CAS: 138112-76-2
Model NO.: 138112-76-2
Shipping Time: Within 24 Hours
Delivery Time: 5-7 Hours
Shipping Method: DHL, FedEx, TNT, Hkems, EMS
Trademark: JCJCHEM
Transport Package: Customized
Specification: powder
Origin: China
HS Code: 156793
Model NO.: 138112-76-2
Shipping Time: Within 24 Hours
Delivery Time: 5-7 Hours
Shipping Method: DHL, FedEx, TNT, Hkems, EMS
Trademark: JCJCHEM
Transport Package: Customized
Specification: powder
Origin: China
HS Code: 156793
Antidepressant Raw Material Drug Agomelatine White Powder CAS: 138112-76-2