Release date: 2007-04-05 British first developed human heart valve Recently, a British research team led by the world's top cardiac surgery experts announced that they have successfully used stem cells to successfully cultivate some human hearts for the first time, which provides for the future use of stem cell technology to cultivate all heart transplant organs. solid foundation. Experts say that if animal experiments are carried out later this year, the replacement organization could be used clinically within three years to provide transplant treatment services for thousands of heart patients.
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Currently, most patients with heart valve disease rely on artificial heart valves. Although this artificial heart valve can save human life, the shortcomings are also obvious, it can not play complex functions like living tissue. When a child transplanting a prosthetic heart valve grows up, it needs to be replaced again. Especially complicated is that patients need to take medicine for life to avoid postoperative complications. Therefore, the use of stem cells to cultivate human replacement tissues has become an important target for contemporary biology.
The use of tissue that matches the patient's genes to replace some of the damaged organs does not produce rejection, and its advantages are outstanding. So far, scientists have developed simple tissues such as tendons, cartilage, and bladder, but have not been able to develop complex organs with three-dimensional structures composed of dozens of different types of cells.
To address the serious shortage of heart transplants, Sir Macdi Yakang, a professor of cardiac surgery at Imperial College London, organized a research team of physicists, biologists, pharmacologists, cylogists and doctors. After 10 years of unremitting efforts, researchers have for the first time developed an alternative tissue with human heart valve function at the Heart Science Center at the Hareford Hospital.
Scientists first mutagenized bone marrow stem cells into heart valve cells by using various chemical and physical signals, and then placed these cells in a scaffold made of collagen to finally grow a disc-shaped heart valve tissue of about 3 cm. The researchers said that later this year, they will transplant these cultivated tissues to pigs or sheep to see if they can function as part of the circulatory system.
Professor McGrady said that it takes about one month to extract the patient's own stem cells and then grow them into appropriate size tissues. However, many patients do not need such special personalized treatments. The reserve organizations that are cultivated in advance are suitable for most patients. .
According to the World Health Organization, in 2005, the number of people dying from cardiovascular disease worldwide reached 15 million. By 2010, about 600,000 people need to replace heart valves. ----Information from: China Medicine 123 Network