Myelofibrosis Treatment Raw Apis Ruxolitinib (CAS 941678-49-5)

October 25, 2018

Model NO.: 941678-49-5
Product Name: Ruxolitinib
CAS No.: 941678-49-5
Mf: C17h18n6
MW: 306.371
Delivery by: DHL, TNT, FedEx, Hkems, UPS, etc
Export Markets: Global
Trademark: NEWBIO
Transport Package: Aluminum Foil Bags
Specification: SGS
Origin: China
HS Code: 0000000000
Model NO.: 941678-49-5
Product Name: Ruxolitinib
CAS No.: 941678-49-5
Mf: C17h18n6
MW: 306.371
Delivery by: DHL, TNT, FedEx, Hkems, UPS, etc
Export Markets: Global
Trademark: NEWBIO
Transport Package: Aluminum Foil Bags
Specification: SGS
Origin: China
HS Code: 0000000000
Chemical Information:
Product Name
Ruxolitinib
Molecular Formula C17H18N6
Molecular Weight 306.371
Storage Store at -20°C 
Targets JAK1  JAK2
IC50 3.3 nM 2.8 nM
Dosage
75 mg/kg
 
Stability
3 years   - 20 ºC powder
6 months  -80 ºC dissolved in a solvent
Solubility Soluble in DMSO > 10 mM
General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
Shipping Condition
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request


Details:
Synonyms:Ruxolitinib;(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile;1H-Pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-,(.beta.R)-;(3R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}-1H-pyrazol-1-yl)propanenitrile;INCB018424 (Ruxolitinib);Jakafi
   
Description:INCB018424 is the first potent, selective inhibitor of JAK1/2 to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
 
 
 
Application:
Mice receiving 75 mg/kg ruxolitinib or vehicle 6 hours prior to and 6 hours after injection of OVA/CpG were analyzed for expression of activation markers on CD11c 1CD81 splenic DCs. Lower expression levels of CD40, CD80, CD86 as well as MHC I and II molecules were detected in ruxolitinib-challenged animals. Next, ruxolitinib or vehicle was fed to mice 6 hours prior to as well as 6 hours and 18 hours after priming with OVA/CpG and adoptive transfer of CFSE-labeled OT-I cells. Analysis of transferred CFSE-labeled OT-I T cells revealed reduced proliferation, CD25 expression, and IFN-production in mice pretreated with ruxolitinib.
 
Other Small Molecular API:
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
Foretinib 849217-64-7
trametinib 871700-17-3
Tivozanib 475108-18-0
Pelitinib  257933-82-7
Cediranib 288383-20-0
Selumetinib 606143-52-6
Tozasertib 639089-54-6
CapMatinib 1029712-80-8
Amuvatinib 850879-09-3
Lestaurtinib 111358-88-4
Brivanib 649735-46-6
 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.

To your satisfiction, here are our advantages:
1) Products can be sent out within 24 hours after payment. 
2) Secure and discreet shipment. 
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.


====================================================
Contact:
Telephone: +86-027-87002705
Mobile: +86-13638641831 +86-13277093700
 
 
FaceBook: https://www.facebook.com/newbiopharma/
Website:  http://www.newbiopharm.com/
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.

 
Chemical Information:
Product Name
Ruxolitinib
Molecular Formula C17H18N6
Molecular Weight 306.371
Storage Store at -20°C 
Targets JAK1  JAK2
IC50 3.3 nM 2.8 nM
Dosage
75 mg/kg
 
Stability
3 years   - 20 ºC powder
6 months  -80 ºC dissolved in a solvent
Solubility Soluble in DMSO > 10 mM
General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
Shipping Condition
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request


Details:
Synonyms:Ruxolitinib;(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile;1H-Pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-,(.beta.R)-;(3R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}-1H-pyrazol-1-yl)propanenitrile;INCB018424 (Ruxolitinib);Jakafi
   
Description:INCB018424 is the first potent, selective inhibitor of JAK1/2 to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
 
 
 
Application:
Mice receiving 75 mg/kg ruxolitinib or vehicle 6 hours prior to and 6 hours after injection of OVA/CpG were analyzed for expression of activation markers on CD11c 1CD81 splenic DCs. Lower expression levels of CD40, CD80, CD86 as well as MHC I and II molecules were detected in ruxolitinib-challenged animals. Next, ruxolitinib or vehicle was fed to mice 6 hours prior to as well as 6 hours and 18 hours after priming with OVA/CpG and adoptive transfer of CFSE-labeled OT-I cells. Analysis of transferred CFSE-labeled OT-I T cells revealed reduced proliferation, CD25 expression, and IFN-production in mice pretreated with ruxolitinib.
 
Other Small Molecular API:
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
Foretinib 849217-64-7
trametinib 871700-17-3
Tivozanib 475108-18-0
Pelitinib  257933-82-7
Cediranib 288383-20-0
Selumetinib 606143-52-6
Tozasertib 639089-54-6
CapMatinib 1029712-80-8
Amuvatinib 850879-09-3
Lestaurtinib 111358-88-4
Brivanib 649735-46-6
 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.

To your satisfiction, here are our advantages:
1) Products can be sent out within 24 hours after payment. 
2) Secure and discreet shipment. 
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.


====================================================
Contact:
Telephone: +86-027-87002705
Mobile: +86-13638641831 +86-13277093700
 
 
FaceBook: https://www.facebook.com/newbiopharma/
Website:  http://www.newbiopharm.com/
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.

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