Product Name: Adefovir DipivoxilÂ
Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVIR PIVOXIL;Adefovir Dipivoxyl;Bis(Pivaloyloxymethyl)-9-[(R)-2-(Phosphonomethoxy)Ethyl]Adenine;AdefovirDipivoxl 98.5%MinÂ
CAS: 142340-99-6
MF: C20H32N5O8P
MW: 501.47
EINECS: 200-001-8
Product Categories: Active Pharmaceutical Ingredients;Adefovir;APIs;Other Products;Bases &Â Related Reagents;Inhibitors;Intermediates &Â Fine Chemicals;Nucleotides;
Pharmaceuticals;Pharmaceutical raw material;API;Bis-POM PMEA, Preveon, Hepsera
Melting point : 98-102°CÂ
Storage temp. :Â Keep in room temperature .
Merck :Â 14,151
Chemical Properties :Â White SolidÂ
Usage :Â Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis BÂ virus (HBV) to reproduce in the body. It is approved for the treatment of chronic hepatitis BÂ in adults with evidence of active virÂ
Usage :Â A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI) .Â
Regulating human immune systemÂ
Adefovir dipivoxil regulates the immune system and let the immune system to attack liver cells of the intrusion of HBV , and clear the virus, but this method will develop resistance, at the same time for patients with renal dysfunction or potential renal dysfunction risk, the use of adefovir dipivoxil chronic treatment will lead to renal toxicity. If eating 1 mg every day, in the three months will produce nephrotoxicity, this will lead to severe renal failure. These patients should be closely monitoring renal function and making appropriate dosage adjustments.
Bisphosphonates is quick conversion of adefovir dipivoxil in vivo, adefovir dipivoxil is a kind of single adenosine monophosphate acyclic nucleoside analogues, became to activity of the metabolites of adefovir in cellular kinases by phosphorylation in cellular kinases. A Duff Vee two phosphate through the following two ways to suppress HBV DNA polymerase (reverse transcriptase); one is with the natural substrate of deoxyadenosine triphosphate competition, the second is the integration of viral DNA and induce DNA chain elongation terminated. A Duff Vee two phosphate to HBV DNA polymerase inhibition constant (KI) is 0.1μM, but of human DNA polymeraseα and γ is weak and Ki values were 1.18μM and 0.97 μM.
Anti-viral activity: in the human hepatoma cell line transfected with HBV, the concentration of AÂ Duff Vee inhibited 50% viral DNA replication (IC50) is from 0.2 to 2.5uM.Â
Adefovir dipivoxil applies for the treatment of hepatitis BÂ virus replication activity and serum amino acid transfer enzyme and persistently elevated liver decompensation adult patients with chronic hepatitis BÂ patients.
Liver injury is often encountered in the course of hepatitis BÂ treatment, hepatitis BÂ therapy is inappropriate, as well as long-term use of drugs on the liver damage, will lead to the occurrence of liver damage.
After long-term taking adefovir dipivoxil tablets, once the withdrawal will aggravate the damage of liver function. Therefore, for stopping taking the patients should be monitored for liver function.
Adefovir dipivoxil is more moderate suitable for long-term use, suitable for patients with lamivudine resistant patients, their chances of producing drug resistance is small, because the amount is less, side effects are small.
Â
Adefovir dipivoxil Uses
Has a broad spectrum of antiviral activity, can be used for the treatment of chronic hepatitis B . Â
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Product Name: Adefovir DipivoxilÂ
Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVIR PIVOXIL;Adefovir Dipivoxyl;Bis(Pivaloyloxymethyl)-9-[(R)-2-(Phosphonomethoxy)Ethyl]Adenine;AdefovirDipivoxl 98.5%MinÂ
CAS: 142340-99-6
MF: C20H32N5O8P
MW: 501.47
EINECS: 200-001-8
Product Categories: Active Pharmaceutical Ingredients;Adefovir;APIs;Other Products;Bases &Â Related Reagents;Inhibitors;Intermediates &Â Fine Chemicals;Nucleotides;
Pharmaceuticals;Pharmaceutical raw material;API;Bis-POM PMEA, Preveon, Hepsera
Melting point : 98-102°CÂ
Storage temp. :Â Keep in room temperature .
Merck :Â 14,151
Chemical Properties :Â White SolidÂ
Usage :Â Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis BÂ virus (HBV) to reproduce in the body. It is approved for the treatment of chronic hepatitis BÂ in adults with evidence of active virÂ
Usage :Â A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI) .Â
Regulating human immune systemÂ
Adefovir dipivoxil regulates the immune system and let the immune system to attack liver cells of the intrusion of HBV , and clear the virus, but this method will develop resistance, at the same time for patients with renal dysfunction or potential renal dysfunction risk, the use of adefovir dipivoxil chronic treatment will lead to renal toxicity. If eating 1 mg every day, in the three months will produce nephrotoxicity, this will lead to severe renal failure. These patients should be closely monitoring renal function and making appropriate dosage adjustments.
Bisphosphonates is quick conversion of adefovir dipivoxil in vivo, adefovir dipivoxil is a kind of single adenosine monophosphate acyclic nucleoside analogues, became to activity of the metabolites of adefovir in cellular kinases by phosphorylation in cellular kinases. A Duff Vee two phosphate through the following two ways to suppress HBV DNA polymerase (reverse transcriptase); one is with the natural substrate of deoxyadenosine triphosphate competition, the second is the integration of viral DNA and induce DNA chain elongation terminated. A Duff Vee two phosphate to HBV DNA polymerase inhibition constant (KI) is 0.1μM, but of human DNA polymeraseα and γ is weak and Ki values were 1.18μM and 0.97 μM.
Anti-viral activity: in the human hepatoma cell line transfected with HBV, the concentration of AÂ Duff Vee inhibited 50% viral DNA replication (IC50) is from 0.2 to 2.5uM.Â
Adefovir dipivoxil applies for the treatment of hepatitis BÂ virus replication activity and serum amino acid transfer enzyme and persistently elevated liver decompensation adult patients with chronic hepatitis BÂ patients.
Liver injury is often encountered in the course of hepatitis BÂ treatment, hepatitis BÂ therapy is inappropriate, as well as long-term use of drugs on the liver damage, will lead to the occurrence of liver damage.
After long-term taking adefovir dipivoxil tablets, once the withdrawal will aggravate the damage of liver function. Therefore, for stopping taking the patients should be monitored for liver function.
Adefovir dipivoxil is more moderate suitable for long-term use, suitable for patients with lamivudine resistant patients, their chances of producing drug resistance is small, because the amount is less, side effects are small.
Â
Adefovir dipivoxil Uses
Has a broad spectrum of antiviral activity, can be used for the treatment of chronic hepatitis B . Â
 More products you may like
Sulbutiamine CAS 3286-46-2
Aniracetam CAS 72432-10-1
Noopept CAS 157115-85-0
Idra-21 CAS 22503-72-6
4-Aminobutyric acid CAS 56-12-2
NSI-189 Free Base CAS 1270138-40-3
NSI-189 Phosphate CAS 1270138-41-4
9-fluorenol CAS 1689-64-1
Coluracetam CAS 135463-81-9
Sunifiram CAS 314728-85-3
Pramiracetam CAS 68497-62-1
Piracetam CAS 7491-74-9
Oxiracetam CAS 62613-82-5
Fasoracetam CAS 110958-19-5
Nefiracetam CAS 77191-36-7
Centrophenoxine CAS 3685-84-5
Pikamilon Sodium CAS 62936-56-5
PRL-8-53 HCL CAS :Â 51352-87-5
Â
Levodopa(L-DOPA) CAS :Â 59-92-7
Etiracetam(UCB-6474) CAS :Â 33996-58-6
Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6
Model NO.: 142340-99-6
CAS: 142340-99-6
Appearance: White Crystalloid Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems
Alias: Adefovir Dipivoxil
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 1kg/25kg/package
Origin: China
HS Code: 121425246
Model NO.: 142340-99-6
CAS: 142340-99-6
Appearance: White Crystalloid Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems
Alias: Adefovir Dipivoxil
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 1kg/25kg/package
Origin: China
HS Code: 121425246
Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6