Distribution and evolution of pericytes in infantile hemangiomas

Release date: 2009-03-18



On March 16th, Chinese researchers observed the distribution, phenotype and evolution of pericytes in infantile hemangiomas. The investigators selected 52 infantile hemangioma specimens and used α-SMA as a marker antigen to observe the distribution of pericytes in hemangiomas. The apoptosis of pericytes was observed by transmission electron microscopy and TUNEL staining. The results showed that there were a large number of pericytes in the hemangioma cell mass in the early and middle stages of proliferation. The pericytes and endothelial cells cooperated for microangiogenesis. In the late stage of proliferative, the pericardial cells were apoptotic; in the early stage of remission, there were a few pericytes around the microvessels; Gradually occluded, vascular tumor pericytes also gradually disappeared. Therefore, the researchers concluded that pericytes are one of the major constituent cells of hemangiomas. The pericardial cells and endothelial cells cooperate with microangiogenesis and development to lead the pathological evolution of infantile hemangiomas.
Meditech Medical Network

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