An acute intestinal infectious disease in rabbits caused by Clostridium perfringens type A is characterized by severe diarrhea, faeces, and rapid death. 1 etiology The pathogen is Clostridium perfringens type A. 2 Epidemiology With the exception of suckling rabbits, rabbits of different ages, breeds, and genders are susceptible to this pathogen. With 1 to 3 months of age the highest incidence of pups. Mainly through the digestive tract or damaged mucous membrane infection, the cause of the incentives are improper feeding and management, green feed shortage, low crude fiber content, feeding high-protein feed or long-distance transport, climate change and so on. The disease can occur throughout the year, with multiple winter and spring seasons. 3 clinical symptoms The incubation period is 2 to 3 days and the length can reach 10 days. The clinical features are acute diarrhea and watery diarrhea before death. There was no significant change in spirit and appetite before water diarrhea. After the occurrence of water diarrhea, the spirit is depressed and does not eat. Feces are watery, with a special odor, contaminating the buttocks and hind legs. 4 pathological changes The appearance of the body is not obvious. The stomach is full of chyme, and the mucous membranes at the bottom of the stomach fall off, with ulcers of varying sizes. The small intestine is full of gas and the walls of the intestines are thin and transparent. The cecum and colon are filled with gas and black-green thin contents and can smell a bad smell; the texture of the liver becomes brittle and the spleen is dark brown. 5 diagnosis 5.1 According to the clinical symptoms and pathological changes can make a preliminary diagnosis, the diagnosis should be further laboratory diagnosis. 5.2 Laboratory Diagnosis 5.2.1 Pathogen examination: smear microscopy (blank intestine contents smear, check bacteria), isolation culture (anaerobic liver soup and lamb blood agar plate), toxin separation and identification (animal test and standard Clostridium perfringens typing serum was used for neutralization test). 5.2.2 Serological tests: Agglutination test, neutralization test and SPA-ELISA. 5.3 Differential Diagnosis The disease should be differentiated from coccidiosis, rabbit pasteurellosis, and salmonellosis. 6 control Strengthen feeding and management, reduce feeding of concentrates, increase crude fiber. Frequently used areas should be used for vaccine prevention. Dental Equipment,Dental Supplies,High Speed Handpiece Gd-H501,Dental X-Ray Unit NOUVASANT PHARMhealth LTD. , http://www.nouvasant.com