Pathogenesis of bacterial meningitis

Bacterial meningitis is a terrible disease with a very high mortality rate. It takes only a few hours to get rid of the patient's life after the symptoms appear. After years of research, scientists at the University of Nottingham in the United Kingdom have finally discovered the mechanism by which meningitis bacteria break through the body's natural defense mechanisms and attack the brain.
Childhood bacterial meningitis is almost exclusively caused by the respiratory pathogens Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae, but the mechanism by which these deadly bacteria break through the blood-brain barrier (BBB) ​​has not been understood.
Zui, a research group led by Dr. Ella Elding, a professor of clinical microbiology at the University of Nottingham, recently discovered that all three of these pathogens use human brain vascular endothelial cells (a special filtration system that protects the human brain from disease). The same receptor on the target is targeted so that the organism crosses the blood-brain barrier.
The study, published in the May 13 issue of the Journal of Clinical Research, shows that disrupting or adjusting the interaction of bacteria and receptors can provide unexpected and widespread protection against bacterial meningitis. A target for the prevention and treatment of this disease.

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