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At the Interdisciplinary Meeting on Antimicrobial and Chemotherapy (ICAAC) in San Francisco, USA, researchers at the Case Western Reserve University Medical Center reported new developments in their prevention, resistance to colds and flu. They developed an oral spray that prevents bacteria from entering the body and provides long-lasting bactericidal action that effectively kills 99.9% of infectious microbes in the inhaled air. The researchers pointed out that this is also the first product in the market for anti-respiratory bacteria sprays.
The spray, called Halo Oral Fungicide (Halo), was developed by Osis Consumer Healthcare, Cleveland, USA. "Respiratory diseases are the leading cause of morbidity and mortality worldwide, but efforts to prevent viral infections have had little effect," said Frank Esper, lead author of the paper and associate professor at Case Western Reserve University School of Medicine. "Our The new product is the only spray that protects people from airborne flu and rhinovirus infections."
The team used glycerin and xanthan gum as a microbial barrier and combined with the broad-spectrum anti-infective formulation cetylpyridinium chloride (CPC) to combat a variety of respiratory diseases. They used the popular H1N1 virus in 2009 as a prototype to test the anti-infective efficacy of sprays in cell culture assays.
"Glycerin and xanthan gum can trap microorganisms in the air and prevent them from entering the body system, and CPC can kill them," Esper explained. At the meeting, he reported on Halo's significant benefits in assisting anti-infectives, reducing epidemics, irregular and widespread epidemic viral infections. Halo is particularly helpful in preventing immune damage due to impaired immune function due to factors such as chronic lung disease. Patients with respiratory diseases, as well as in the military.
Mohamed Ganom, director of the Medical Mycology Center at the School of Medicine, reported on Halo's effectiveness in combating pathogens.
He pointed out that airborne pathogens usually enter the human body from the mouth, causing respiratory infections. Targeting these bacteria is an effective way to prevent infection. In addition, initial data also showed that Halo can completely kill 11 clinical strains of B. pertussis. The test results show that a person using 3 Halo sprays can maintain the effect for 6 hours to kill the bacteria in the inhaled air, even if eating or drinking.
“People are inevitably exposed to airborne micro-organisms, especially in crowded environments and when traveling,†Ganom said. “This spray is different from other products that enhance immune function, anti-object surfaces or bacteria on the hands. Halo is the first of its kind to protect people from airborne microbial infections."