After quitting smoking, tobacco can control your genes for up to 30 years! September 27, 2016 Source: WuXi PharmaTech Baby Feeding,Kids Water Bottle,Baby Feeding Set,Soft Baby Feeding Spoon NINGBO YOUHE MOTHER&BABY PRODUCTS CO.,LTD , https://www.oembreastpump.com
After quitting smoking, tobacco can control your genes for up to 30 years!
Recently, researchers have found that smoking can leave a "footprint" in the human genome in the form of DNA methylation. A new study published in the authoritative cardiovascular genetics journal Circulation: Cardiovascular Genetics suggests that DNA methylation may be an important indicator of a personal smoking history and may provide a potential treatment for disease.
Dr. Stephanie J. London, deputy director of the Department of Epidemiology at the National Institutes of Health Sciences, and the author of the research paper, said: "These results are important - gene methylation is gene expression One of the mechanisms of regulation affects which genes are activated – these activated genes greatly affect the development of smoking-related diseases. Equally important, our study found that even if they stopped smoking for a while, they still saw smoking against them. The influence of genetic information material DNA."
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Many years of medical data show that even after decades of smoking cessation, those who have smoked have long-term risk of developing a disease, including cancer, chronic obstructive pulmonary disease and brain stroke. However, we know very little about the molecular mechanisms that contribute to these long-term effects. Previous genetic studies have shown that DNA methylation sites are involved in coronary heart disease and lung disease, and play an important pathogenic role.
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In the study, scientists used nearly 16,000 blood samples to perform large-scale data analysis of DNA methylation sites, especially comparing the DNA methylation sites of current and former smokers with those who never smoked. . They found that smoking-related DNA methylation sites involve more than 7,000 genes, that is, associated with nearly one-third of known human genes. For those who have quit smoking, most of the DNA methylation sites return to the level of never-smokers within 5 years of smoking cessation. However, there are still some changes in DNA methylation sites that last up to 30 years. The most statistically significant changes in methylation sites are enriched in a number of related genes caused by smoking, such as cardiovascular disease and certain cancers.
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Researchers believe that these long-lasting changes in methylation sites may mark the genes of former smokers and still potentially increase their risk of certain diseases. The discovery of smoking-related DNA methylation sites can be exploited as biomarkers to assess a patient's smoking history and potentially develop innovative treatments for these methylation sites.
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Dr. Roby Joehanes, the first author of this article and Harvard Medical School, said: "Our research has found convincing evidence that smoking can last for more than 30 years at a molecular level. Encouragingly, once you After 5 years of cessation of smoking, most of the DNA methylation signals may return to the level of never-smokers, which means your body is trying to heal the harmful effects of smoking on the body."