Found that functional integration can improve the antibacterial ability of organisms

Release date: 2007-01-19

It has been found that a "resistance movement" initiated by antibiotics to bacteria through functional integration can be a failed battle. To this end, the scientists at the Weizmann Institute have designed a more powerful weapon by integrating the main functions of two different types of weapons that the organism uses innately, laying the foundation for the development of more effective antibiotics.
There are two kinds of antibiotic-related weapons in the organism. The first is a "magnetic" weapon, a natural antibiotic that all organisms can produce. These antibacterial peptides (AMPs) are positively charged and can be attracted to the surface of a negatively charged bacteria to exert its antibacterial effect. The second is a "cleaning weapon" called lipopeptide, which is made only from bacteria and fungi. This weapon contains a fatty acid chain that dissolves the fat film in the fungus.
The researchers at the Weizmann Institute of Biochemistry, led by Prof. Yehr Xie, successfully integrated the functions of AMPs with lipopeptides to develop a synthetic lipopeptide that carries a positive charge and is capable of dissolving fat.
Researchers have created a series of weapons by changing the length of fatty acid chains and the order of positively charged amino acids. Some of these weapons are for bacteria and fungi, others are for only one of them. In addition, the researchers are also preparing to design these new synthetic peptides (protein fragments) into fragments containing only four amino acids.
Due to the shorter length of the synthetic peptide, this makes it easier to synthesize and thus the synthesis cost is lower. Moreover, more targeted drugs can be designed for different types of bacterial and fungal infections. Therefore, the researchers believe that this discovery is conducive to the development of new drugs, and its application prospects are very broad.
—— Information from: Meditech Medical Network

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