Sci Rep: Say goodbye to the gym! Scientists use gelatin to create stronger muscle tissue

Release date: 2016-07-05

Recently, in a research report published in the international journal Scientific Reports , researchers from the University of Southern California have designed a method to create strong and robust muscle fibers. The muscles that researchers use gelatin can make. Grow on a small stent or chip mold.

During normal embryonic development, skeletal muscle begins to form when muscle cells fuse to form muscle fibers (muscle tubes). In the past, researchers have studied mice and found that when the muscle tubes of mice develop for about a week or cannot continue to grow, the muscles The tube can be separated or layered from a plastic coated plastic scaffold. In this study, researchers used gelatin to make gel scaffolds, which are naturally occurring muscle collagen derivatives that can better help researchers conduct research. The researchers found that after three weeks, most of the mouse myotubes still adsorbed on the gelatin "chip" and its length was longer and longer.

Researchers predict that human myotubes will also grow well on gelatin "chips", and these newly created improved muscle chip tissues can be used to study human muscle development and disease, but also To conduct a variety of tests for new potential drugs.

Researcher McCain said that a variety of skeletal muscle-related diseases and physical disorders, including muscular dystrophy, can significantly reduce human quality of life by developing a new platform that is cheap and easy to obtain or that can help scientists perform skeletal muscle in the laboratory. Related research, we hope this article studies or helps develop a variety of therapies for the treatment of disease. In future plans, researchers will use gelatin chips to study amyotrophic lateral sclerosis (ALS), which can severely disrupt cross-linking between motor neurons and muscle cells (neuromuscular junctions, NMJs), while McCain and Other researchers will also use the skin or blood cells from the body of ALS patients to study muscle nerve junctions on gelatin chips.

Source: Bio Valley

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